WebSep 1, 2024 · During CSI, hematological toxicity leading to treatment breaks was observed in 11 (39.3 %) patients, of which grade 3 and 2 toxicities were seen in ten and one patients respectively. Younger age (<10 years) at diagnosis was significantly associated with the development of hematological toxicity (p = 0.028, Chi-Square). WebSep 13, 2024 · IMPT using PBS delivery will be considered to be feasible as a VBS technique for CSI in pediatric patients if the rate of grade 3/4 hematologic toxicity were no more than 5% within 3 months after the completion of radiation treatment, within the range associated with conventional techniques of CSI. Toxicity will be assess using Common ...
SUMMARY OF SAFETY AND EFFECTIVENESS DATA (SSED)
WebJun 22, 2024 · I personally believe in protons to reduce CSI toxicity (acute and long-term marrow) but maybe that's overstated. Agree with intrathecal herceptin for her2+. Getting intrathecal at my institution is very challenging. I am posting an example patient, but I am the CNS attending so I have a case like this with varying histologies and receptor ... Craniospinal irradiation (CSI) plays an essential role in treating various tumors with predilection for leptomeningeal dissemination. Many patients have excellent clinical outcomes; however, conventional photon … See more The authors report no funding sources supporting this research. Conflict of interest statement. None declared. See more Patient, tumor, and treatment characteristics are reported in Table 1. A variety of histologies were treated, with medulloblastoma the … See more To our knowledge this is the largest study of nonpediatric patients treated with p-CSI, representing a spectrum of patients with a variety of histologies who received different … See more litter of puppies image
Craniospinal irradiation(CSI) in patients with …
WebFeb 20, 2013 · Hematologic toxicity from CSI may limit a patient’s ability to tolerate a full course of chemotherapy after CSI, administered either for consolidation or as salvage for recurrence. Vertebral body-sparing p-CSI has been proposed to reduce hematologic toxicity in patients whose vertebrae are fully developed, since vertebral body … WebApr 21, 2024 · Traditionally, CSI has been delivered with 2- or 3-dimenstional conformal photon-based radiation techniques that carry an increased risk of significant toxicities … WebJun 1, 2013 · Hematologic toxicity from CSI may limit a patient's ability to tolerate a full course of chemotherapy after CSI, administered either for consolidation or as salvage for recurrence. Vertebral body-sparing p-CSI has been proposed to reduce hematologic toxicity in patients whose vertebrae are fully developed because vertebral body … litter of puppies names