WebJan 13, 2024 · lysosomes and CTSB. HK-2 ce lls were treated with dif ferent. concen trati on of LPS (1 0 m g/mL, 25 m g/mL, 5 0 m g/mL) for 24 h, 48 h and subjected to the CCK8 assay. The results showed that LPS. WebIndeed, the protein level of the full-length TRPML1 was increased in Ctsb −/− BMDMs, whereas differential levels of the transcription of the gene encoding TRPML1 was not observed between untreated WT and Ctsb −/− BMDMs (Fig. 7, A and B), suggesting decreased cleavage of TRPML1 in Ctsb −/− BMDMs. We enriched lysosome fractions …
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WebOct 10, 2024 · Glucose metabolism promotes O-GlcNAcylation of the lysosome-encapsulated protease Cathepsin B at serine 210, mediated by lysosome-localized O-GlcNAc transferase (OGT), elevating mature Cathepsin B in macrophages and its secretion in the tumor microenvironment (TME). Loss of OGT in macrophages reduces O … WebDec 17, 2024 · Among eleven members of the cysteine cathepsin family in lysosome, CTSB plays a unique role in the regulation of autophagy, cellular stress signaling, and cell death in cancer [13].We first analyzed the expression and activity of CTSB in PANC1 and MIAPaCa2 cells, which are human pancreatic cancer cell lines sensitive to ferroptosis … sims 4 ghost added to household glitch
Zhefu (Jeff) Dai - Sientist I - IGM Biosciences, Inc.
WebApr 13, 2024 · Cathepsin B (CTSB), a kind of lysosomal cysteine protease, is essential for a tremendous amount of biological processes in cancers, such as metastasis, invasion, and angiogenesis [1,2,3,4].CTSB is a desirable biomarker in the detection of numerous malignancies including glioblastoma, oral, laryngeal, gastric, esophageal, pancreatic, … WebJan 13, 2024 · White arrowheads, extralysosomal CTSB activity (red dots outside white lysosomes); yellow arrowhead, lysosomal CTSB activity (red dots co-localizing with white lysosomes). d Quantification of ( c ). WebNov 28, 2024 · The permeabilization and rupture of lysosomes after stress is a biological process relevant to immunity, neurodegeneration and cancer. ... (CtsB), Cathepsin L (CtsL) or Cathepsin S (CtsS) ... rbt graphing