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Toxin extrusion protein

WebDec 1, 2001 · Mediates the efflux of cationic compounds, such as the model cations, tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), the drugs procainamide, … Multi-antimicrobial extrusion protein (MATE) also known as multidrug and toxin extrusion or multidrug and toxic compound extrusion is a family of proteins which function as drug/sodium or proton antiporters. See more The MATE proteins in bacteria, archaea and eukaryotes function as fundamental transporters of metabolic and xenobiotic organic cations. See more The multidrug efflux transporter NorM from V. parahaemolyticus which mediates resistance to multiple antimicrobial agents (norfloxacin, kanamycin, ethidium bromide etc.) and its … See more • Solute carrier family • Resistance-Nodulation-Cell Division Superfamily (RND) See more These proteins are predicted to have 12 alpha-helical transmembrane regions, some of the animal proteins may have an additional C-terminal helix. The X-ray structure of the NorM was determined to 3.65 Å, revealing an outward-facing conformation with … See more The following human genes encode MATE proteins: • SLC47A1 • SLC47A2 See more

MATE1 - Transporters - Solvo Biotechnology

WebOrganic cation transporters (OCTs) and multidrug and toxin extrusion proteins (MATEs) transport metformin to the l … Houttuynia cordata extract increased systemic exposure and liver concentrations of metformin through OCTs and MATEs in rats Phytother Res. 2024 Jun;32(6):1004-1013.doi: 10.1002/ptr.6036. Epub 2024 Feb 26. Authors WebAug 31, 2024 · Twelve healthy subjects received a multidrug and toxin exclusion protein (MATE) inhibitor (pyrimethamine, 10, 25, and 75 mg) in a crossover fashion to identify an appropriate endogenous biomarker to assess MATE1/2-K-mediated DDI in the kidneys. Metformin (500 mg) was also given as reference probe drug for MATE1/2-K. theme park cafeteria https://blissinmiss.com

Organic Cation Transporter - an overview ScienceDirect Topics

WebThe substrate specificities of human (h) multidrug and toxin extrusion (MATE) 1 and hMATE2-K were examined to find functional differences between these two transporters by the transfection of the cDNA of hMATE1 and hMATE2-K into HEK293 cells. WebAmong the SLC47 family, multidrug and toxin extrusion protein 1, or MATE1 (SLC47A1), an organic cation/proton exchanger, mostly expressed in hepatocytes and renal tubular cells, … WebMATE1 (multidrug and toxin extrusion 1) Aliases: none Gene name: Solute carrier family 47 member 1 (SLC47A1) Summary MATE1 is an apically expressed poly-specific proton antiporter which mediates the efflux of diverse substrates, primarily organic cations, in the kidney and the liver. tiger shroff and disha

Multidrug and toxin extrusion protein 1 - Wikipedia

Category:Multidrug and toxin extrusion protein 1 - Wikipedia

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Toxin extrusion protein

Impact of Direction of Transport on the Evaluation of Inhibition ...

WebNov 15, 2013 · The nephrotoxicity limits the clinical application of cisplatin. Human organic cation transporter 2 (OCT2) and multidrug and toxin extrusion proteins (MATEs) work in concert in the elimination of cationic drugs such as cisplatin from the kidney. We hypothesized that co-administration of ondansetron … WebNov 10, 2024 · A Physiologically-Based Pharmacokinetic Model of Trimethoprim for MATE1, OCT1, OCT2, and CYP2C8 Drug-Drug-Gene Interaction Predictions Authors Denise Türk 1 , Nina Hanke 1 , Thorsten Lehr 1 Affiliation 1 Clinical Pharmacy, Saarland University, 66123 Saarbrücken, Germany. PMID: 33182761 PMCID: PMC7696733 DOI: …

Toxin extrusion protein

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Web3.1.3 Multidrug and toxin extrusion protein 2 (MATE2) MATE2 is a primarily of organic cations and act as a poly-specific efflux transporters for diverse substrates. It is an important player for renal excretion of exogenous and … WebMultidrug and toxin extrusion protein 1 DrugBank Online Multidrug and toxin extrusion protein 1 Details Name Multidrug and toxin extrusion protein 1 Synonyms MATE-1 MATE1 Solute carrier family 47 member 1 Gene Name SLC47A1 Organism Humans Amino …

WebDec 5, 2005 · In mammals, toxic electrolytes of endogenous and exogenous origin are excreted through the urine and bile. Before excretion, these compounds cross numerous …

WebAmong the SLC47 family, multidrug and toxin extrusion protein 1, or MATE1 (SLC47A1 ), an organic cation/proton exchanger, mostly expressed in hepatocytes and renal tubular cells, … WebJun 13, 2005 · Pharmacodynamics. Pyrimethamine is an antiparasitic compound commonly used as an adjunct in the treatment of uncomplicated, chloroquine resistant, P. falciparum malaria. Pyrimethamine is a folic acid antagonist and the rationale for its therapeutic action is based on the differential requirement between host and parasite for nucleic acid ...

WebNov 4, 2024 · Over the last few decades, proteins and peptides have become increasingly more common as FDA-approved drugs, despite their inefficient delivery due to their inability to cross the plasma membrane. In this context, bacterial two-component systems, termed AB toxins, use various protein-based membrane translocation mechanisms to deliver …

WebTwelve healthy subjects received a multidrug and toxin exclusion protein (MATE) inhibitor (pyrimethamine, 10, 25, and 75 mg) in a crossover fashion to identify an appropriate … theme park busyWebMar 9, 2024 · This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the bacterial MATE (multidrug and toxin extrusion) protein family responsible for drug resistance. tiger shroff and disha patani kissingWebThe OCT proteins are usually 500–600 amino acids in length. Also, the SLC22A family contains the organic cation and carnitine transporters (OCTN1 and OCTN2). These transport proteins are predicted to contain 12 transmembrane domains with intracellular N- … tiger shroff and tara sutaria moviesWebRenal effects: BIC is an inhibitor of organic cation transporter 2 and multidrug and toxin extrusion protein 1, so it decreases tubular secretion of creatinine. This increases serum … tiger shroff choti bachi ho kya movieWebProtein extrusion has frustrated earlier predictions regarding its impact in the development of food products. The main reason for this disappointing performance has been its failure … tiger shroff body fat percentageWebFig. 15. Amino acid sequences of sixteen selected toxins or toxin like peptides known or presumed to adopt a three-fingered fold. Toxins 1–4 are erabutoxins c, a, b, and d from … theme park builder gameWebJan 9, 2009 · H+/organic cation antiporters (multidrug and toxin extrusion: MATE1 and MATE2-K) play important roles in the renal tubular secretion of cationic drugs. We have recently identified a regulatory ... theme park cameron highland