WebDec 1, 2001 · Mediates the efflux of cationic compounds, such as the model cations, tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), the drugs procainamide, … Multi-antimicrobial extrusion protein (MATE) also known as multidrug and toxin extrusion or multidrug and toxic compound extrusion is a family of proteins which function as drug/sodium or proton antiporters. See more The MATE proteins in bacteria, archaea and eukaryotes function as fundamental transporters of metabolic and xenobiotic organic cations. See more The multidrug efflux transporter NorM from V. parahaemolyticus which mediates resistance to multiple antimicrobial agents (norfloxacin, kanamycin, ethidium bromide etc.) and its … See more • Solute carrier family • Resistance-Nodulation-Cell Division Superfamily (RND) See more These proteins are predicted to have 12 alpha-helical transmembrane regions, some of the animal proteins may have an additional C-terminal helix. The X-ray structure of the NorM was determined to 3.65 Å, revealing an outward-facing conformation with … See more The following human genes encode MATE proteins: • SLC47A1 • SLC47A2 See more
MATE1 - Transporters - Solvo Biotechnology
WebOrganic cation transporters (OCTs) and multidrug and toxin extrusion proteins (MATEs) transport metformin to the l … Houttuynia cordata extract increased systemic exposure and liver concentrations of metformin through OCTs and MATEs in rats Phytother Res. 2024 Jun;32(6):1004-1013.doi: 10.1002/ptr.6036. Epub 2024 Feb 26. Authors WebAug 31, 2024 · Twelve healthy subjects received a multidrug and toxin exclusion protein (MATE) inhibitor (pyrimethamine, 10, 25, and 75 mg) in a crossover fashion to identify an appropriate endogenous biomarker to assess MATE1/2-K-mediated DDI in the kidneys. Metformin (500 mg) was also given as reference probe drug for MATE1/2-K. theme park cafeteria
Organic Cation Transporter - an overview ScienceDirect Topics
WebThe substrate specificities of human (h) multidrug and toxin extrusion (MATE) 1 and hMATE2-K were examined to find functional differences between these two transporters by the transfection of the cDNA of hMATE1 and hMATE2-K into HEK293 cells. WebAmong the SLC47 family, multidrug and toxin extrusion protein 1, or MATE1 (SLC47A1), an organic cation/proton exchanger, mostly expressed in hepatocytes and renal tubular cells, … WebMATE1 (multidrug and toxin extrusion 1) Aliases: none Gene name: Solute carrier family 47 member 1 (SLC47A1) Summary MATE1 is an apically expressed poly-specific proton antiporter which mediates the efflux of diverse substrates, primarily organic cations, in the kidney and the liver. tiger shroff and disha